Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Cancer Res Treat. 2009 Sep;41(3):155-63. doi: 10.4143/crt.2009.41.3.155. Epub 2009 Sep 28.
Leptin is a multifunctional hormone that's produced by adipose tissue and leptin is involved in the regulation of food intake and energy balance. The aims of this study were to determine the leptin and leptin receptor (Ob-R) expressions in human breast cancer and their corresponding influence on the prognosis of patients with breast cancer.
We examined the correlations between the leptin and Ob-R expressions and the breast cancer-related pathobiologic markers by performing immunohistochemistry in 517 patients with breast cancer. We analyzed the leptin and Ob-R expressions with respect to overall survival and relapse-free survival (RFS).
Positive cytoplasmic immunoreactivity for leptin was noted in 39% of the patients and 79% of the patients showed positive cytoplasmic immunoreactivity for Ob-R. The expression of leptin in breast cancer was correlated with a high Ki-67 labeling index (p=0.019). Based on the univariate survival analysis, the clinicopathologic variables with prognostic value included the histologic grade, the T stage, the N stage, the HER2 status, the Bcl-2, p53 and Ki-67 expressions (p<0.05). The patients with leptin-positive breast cancers and a negative hormone receptor status had a significantly longer overall survival (p=0.021). Multivariate survival analysis showed that a positive expression of leptin was an independent prognostic marker for overall survival (hazard ratio, 0.20; 95% CI, 0.04~0.99; p=0.05).
A leptin expression in breast cancer is significantly associated with the Ki-67 labeling index, and this suggests there is an association of a leptin expression with the proliferation activity. In addition, a leptin expression is an indicator of better survival for breast cancer patients.
瘦素是一种由脂肪组织产生的多功能激素，参与调节食物摄入和能量平衡。本研究的目的是确定瘦素和瘦素受体（Ob-R）在人乳腺癌中的表达及其对乳腺癌患者预后的影响。
我们通过对 517 例乳腺癌患者进行免疫组织化学检测，研究了瘦素和 Ob-R 表达与乳腺癌相关病理生物学标志物之间的相关性。我们分析了瘦素和 Ob-R 表达与总生存和无复发生存（RFS）的关系。
39%的患者出现细胞质阳性免疫反应，79%的患者出现细胞质阳性免疫反应。乳腺癌中瘦素的表达与 Ki-67 标记指数高相关（p=0.019）。基于单因素生存分析，具有预后价值的临床病理变量包括组织学分级、T 分期、N 分期、HER2 状态、Bcl-2、p53 和 Ki-67 表达（p<0.05）。瘦素阳性乳腺癌且激素受体阴性的患者总生存时间明显延长（p=0.021）。多因素生存分析显示，瘦素阳性表达是总生存的独立预后标志物（风险比，0.20；95%置信区间，0.04~0.99；p=0.05）。
乳腺癌中瘦素的表达与 Ki-67 标记指数显著相关，提示瘦素表达与增殖活性有关。此外，瘦素表达是乳腺癌患者生存更好的指标。
