Breast Cancer Department, MD Anderson Cancer Center, Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Front Immunol. 2021 Nov 15;12:784823. doi: 10.3389/fimmu.2021.784823. eCollection 2021.
Adipose tissue secretes various peptides, including leptin. This hormone acts through the leptin receptor (Ob-R), which is expressed ubiquitously on the surface of various cells, including breast cancer cells and immune cells. Increasing evidence points to an interaction between the tumor microenvironment, tumor cells, and the immune system. Leptin plays an important role in breast cancer tumorigenesis and may be implicated in activation of the immune system. While breast cancer cannot be considered an immunogenic cancer, the triple-negative subtype is an exception. Specific immune cells - tumor infiltrating lymphocytes - are involved in the immune response and act as predictive and prognostic factors in certain breast cancer subtypes. The aim of this article is to review the interaction between adipose tissue, through the expression of leptin and its receptor, and the adaptive immune system in breast cancer.
脂肪组织分泌各种肽类，包括瘦素。这种激素通过瘦素受体（Ob-R）发挥作用，Ob-R 广泛表达于各种细胞表面，包括乳腺癌细胞和免疫细胞。越来越多的证据表明，肿瘤微环境、肿瘤细胞和免疫系统之间存在相互作用。瘦素在乳腺癌的发生发展中起重要作用，可能与免疫系统的激活有关。虽然乳腺癌不能被认为是一种免疫原性癌症，但三阴性亚型是一个例外。特定的免疫细胞 - 肿瘤浸润淋巴细胞 - 参与免疫反应，并在某些乳腺癌亚型中作为预测和预后因素。本文旨在综述脂肪组织通过瘦素及其受体的表达与乳腺癌适应性免疫系统之间的相互作用。
