van de Kerkhof P C, Timmerman M G
Department of Dermatology, University of Nijmegen, The Netherlands.
Acta Derm Venereol. 1990;70(5):434-7.
Clobetasol-17-propionate (CP) and crude coal tar (CT) have an anti-inflammatory potential. Both agents have been advocated to suppress irritation of the skin during dithranol treatment. The effect of CP and CT on dithranol-induced irritation was studied by the assessment of erythema and measurement of alkaline phosphatase (ALP) as a direct reflection of the metabolic activity of the endothelial cells. Dithranol was applied for 2 h in the relatively high concentration of 10%, which resulted in a marked inflammation of the skin in all volunteers. Neither CP nor CT influenced the erythema. In contrast, CP and CT had a synergistic effect on the dithranol-induced induction of ALP. In conclusion, the present study indicates that CP and CT are not indicated for the treatment of dithranol-induced irritation.
丙酸氯倍他索（CP）和粗煤焦油（CT）具有抗炎潜力。两种药物均被提倡用于抑制地蒽酚治疗期间皮肤的刺激。通过评估红斑和测量碱性磷酸酶（ALP）作为内皮细胞代谢活性的直接反映，研究了CP和CT对地蒽酚诱导的刺激的影响。以10%的相对高浓度应用地蒽酚2小时，这在所有志愿者中均导致皮肤明显炎症。CP和CT均未影响红斑。相比之下，CP和CT对地蒽酚诱导的ALP诱导具有协同作用。总之，本研究表明CP和CT不适合用于治疗地蒽酚诱导的刺激。
