National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
J Biomed Mater Res B Appl Biomater. 2010 Feb;92(2):307-16. doi: 10.1002/jbm.b.31516.
Collagen and hydrazide-functionalized hyaluronic acid derivatives were hybridized by gelating and genipin crosslinking to form composite hydrogel. The study contributed to the understanding of the effects of adipic dihydrazide modification on the physicochemical and biological properties of the collagen/hyaluronic acid scaffold. The investigation included morphology observation, mechanical measurement, swelling evaluation, and collagenase degradation. The results revealed that the stability of composites was increased through adipic dihydrazide modification and genipin crosslinking. The improved biocompatibility and retention of hyaluronic acid made the composite material more favorable to chondrocytes growing, suggesting the prepared scaffold might be high potential for chondrogenesis.
胶原和酰肼功能化透明质酸衍生物通过凝胶化和京尼平交联杂交形成复合水凝胶。该研究有助于了解己二酰二肼改性对胶原/透明质酸支架理化性质和生物学性质的影响。研究包括形态观察、力学测量、溶胀评价和胶原酶降解。结果表明，己二酰二肼改性和京尼平交联增加了复合材料的稳定性。透明质酸生物相容性和保留性的提高使复合材料更有利于软骨细胞生长，表明所制备的支架可能具有较高的软骨生成潜力。
