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用于肺癌治疗的紫杉醇靶向给药的氧化锌量子点新型表面修饰

Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment.

作者信息

Xie Chuan, Zhan Yan, Wang Peng, Zhang Bo, Zhang Yukun

机构信息

Department of Thoracic Surgery, Taian City Central Hospital, Tai'an, Shandong, China.

出版信息

Dose Response. 2020 May 21;18(2):1559325820926739. doi: 10.1177/1559325820926739. eCollection 2020 Apr-Jun.

DOI:10.1177/1559325820926739
PMID:32499674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7243397/
Abstract

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

摘要

己二酸二酰肼和肝素附着在氧化锌量子点表面，氧化锌-己二酸二酰肼-肝素纳米复合物被用作药物递送系统来递送紫杉醇进行化疗。通过傅里叶变换红外光谱确认了表面修饰和紫杉醇的负载，其特征在于来自己二酸二酰肼、肝素和紫杉醇官能团的特征峰。研究了pH对药物释放的影响，并对A549细胞进行了细胞毒性研究。对雄性Wistar大鼠进行了药代动力学研究。体外和体内研究均表明，氧化锌-己二酸二酰肼-肝素-紫杉醇纳米复合物能够以更可控的方式递送紫杉醇，并且它有潜力成为一种用于癌症治疗的高效药物递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/8d7b93e37483/10.1177_1559325820926739-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/16cce56953e9/10.1177_1559325820926739-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/69b0bacc213f/10.1177_1559325820926739-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/35c9c51f6985/10.1177_1559325820926739-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/c08bb3d3aa86/10.1177_1559325820926739-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/1ac6a4afdb90/10.1177_1559325820926739-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/8d7b93e37483/10.1177_1559325820926739-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/16cce56953e9/10.1177_1559325820926739-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/69b0bacc213f/10.1177_1559325820926739-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/35c9c51f6985/10.1177_1559325820926739-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/c08bb3d3aa86/10.1177_1559325820926739-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/1ac6a4afdb90/10.1177_1559325820926739-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8783/7243397/8d7b93e37483/10.1177_1559325820926739-fig6.jpg

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