Riju R, Jadhav Santosh, Kanthaswamy Rajasekhar, Jacob Pradeep, Nair C Gopalakrishnan
Department of General and Endocrine Surgery, Amrita Institute of Medical Sciences, Kochi 682026.
J Indian Med Assoc. 2009 Apr;107(4):223-5.
Role of total thyroidectomy in treatment of patients with benign diseases of thyroid gland remains controversial. The hypothesis behind the study is that total thyroidectomy can be performed in all benign thyroid diseases with equal rate of immediate and late complications compared with those of subtotal thyroidectomy. The retrospective case control study was done by reviewing the case records of patients with benign thyroid diseases involving both lobes operated during May, 2002 to September, 2004. The minimum follow-up period was 3 years. Of the 189 patients included in the study 94 underwent total thyroidectomy and 95 patients underwent subtotal thyroidectomy. There was no incidence of permanent recurrent laryngeal nerve paralysis in both groups. Temporary unilateral recurrent laryngeal nerve paralysis occurred in 3 patients (3.2%) in total thyroidectomy group and 1 (1.1%) patient in subtotal thyroidectomy group, which was not statistically significant (p = 0.307). Temporary hypocalcaemia was noted in 10 patients of total thyroidectomy group (10.6%) and 3 patients of subtotal thyroidectomy group (3.2%). Permanent hypocalcaemia was noted in 2 patients each in total thyroidectomy group and subtotal thyroidectomy group (p = 0.991). Total thyroidectomy is an acceptable alternative to subtotal thyroidectomy in benign diseases, considering the higher rate of postoperative morbidity in recurrent goitres.
全甲状腺切除术在甲状腺良性疾病患者治疗中的作用仍存在争议。该研究背后的假设是,与次全甲状腺切除术相比,全甲状腺切除术可用于所有甲状腺良性疾病,其近期和远期并发症发生率相当。通过回顾2002年5月至2004年9月期间接受双侧手术的甲状腺良性疾病患者的病例记录进行了回顾性病例对照研究。最短随访期为3年。在纳入研究的189例患者中,94例行全甲状腺切除术,95例行次全甲状腺切除术。两组均未发生永久性喉返神经麻痹。全甲状腺切除术组有3例患者(3.2%)发生暂时性单侧喉返神经麻痹,次全甲状腺切除术组有1例患者(1.1%)发生,差异无统计学意义(p = 0.307)。全甲状腺切除术组有10例患者(10.6%)出现暂时性低钙血症,次全甲状腺切除术组有3例患者(3.2%)出现。全甲状腺切除术组和次全甲状腺切除术组各有2例患者出现永久性低钙血症(p = 0.991)。考虑到复发性甲状腺肿术后发病率较高,全甲状腺切除术是甲状腺良性疾病次全甲状腺切除术的一种可接受的替代方法。