First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan.
Autoimmunity. 2009 Aug;42(5):399-405. doi: 10.1080/08916930902960354.
(NZW x BXSB)F1 mice (W/BF1 mice) have been reported to develop autoimmune diseases with aging. We have also reported that the number of dendritic cells (DCs) increases in the various organs, and that the B-cell response to LPS or interleukin-4 plus anti-mu increase with aging in W/BF1 mice. In the present experiment, we show that many DCs exist not only in the T-cell area but also in the B-cell area and the sinus in the spleen of aged W/BF1 mice, and that the coculturing of DCs from aged W/BF1 mice and B cells from disease-free young W/BF1 mice produces much more IgG and IgM than normal mice. These results suggest that an abnormal distribution of DCs and the interaction of DCs and B cells induce the hyperproduction of immunoglobulin in aged W/BF1 mice.
(NZW x BXSB)F1 小鼠（W/BF1 小鼠）随着年龄的增长会发展出自免疫疾病。我们也已经报道了在各种器官中树突状细胞（DCs）数量的增加，并且在 W/BF1 小鼠中，随着年龄的增长，对 LPS 或白细胞介素-4 加抗 μ 的 B 细胞反应增加。在本实验中，我们表明，许多 DCs 不仅存在于 T 细胞区，而且存在于 B 细胞区和老龄 W/BF1 小鼠脾脏的窦中，并且来自老龄 W/BF1 小鼠的 DCs 与来自无病年轻 W/BF1 小鼠的 B 细胞共培养产生的 IgG 和 IgM 比正常小鼠多得多。这些结果表明，DCs 的异常分布以及 DCs 和 B 细胞的相互作用导致老龄 W/BF1 小鼠中免疫球蛋白的过度产生。
