Department of Internal, Autoimmune and Metabolic Diseases, Medical University of Silesia, ul. Medyków 14, 40-752, Katowice, Poland.
Autoimmunity. 2009 Aug;42(5):459-66. doi: 10.1080/08916930902960339.
The objective of this study was to determine the serum concentration of angiogenic factors (vascular endothelial growth factor, VEGF; transforming growth factor beta, TGF-beta1; hepatic growth factor, HGF; basic fibroblast growth factor, bFGF; tumor necrosis factor alpha, TNF-alpha; soluble vascular endothelial growth factor receptor 1, sVEGF-R1; soluble vascular endothelial growth factor receptor 2, sVEGF-R2), the relationships among them and to assess the relation of their levels with the applied therapy in 48 females with systemic lupus erythematosus (SLE; 37 long-term treated +11 newly diagnosed). The control group consisted of 24 healthy women. A statistically significant increase of sVEGF-R2 and significant decrease of sVEGF-R1 were observed in the subgroup of newly diagnosed SLE patients as compared to the control subjects. No significant differences were found between serum angiogenic factors in the long-term treated subgroup and the control, the long-term treated subgroup and the newly diagnosed SLE patients after a 3-month treatment, and the subgroup of newly diagnosed SLE patients before therapy and after a 3-month treatment. The significant decrease in the serum of sVEGF-R2 was revealed in the subgroup treated for a long-time as compared to the subgroup of newly diagnosed untreated SLE patients. The analysis of relationships between serum concentration of sVEGF-R1 and other cytokines levels revealed positive correlation with concentration of VEGF and TNF-alpha in the total group of patients. In the newly diagnosed untreated subgroup, a strong positive correlation between concentration of sVEGF-R1 and bFGF was observed. Furthermore, a moderate positive correlation between concentration of sVEGF-R1 and the level of VEGF was revealed in the long-term treated patients. The association between sVEGF-R2 and HGF was also noted in this subgroup. The obtained data suggest the necessity of further investigations to determine the importance of angiogenic factors in pathogenesis and therapy of SLE.
本研究旨在测定血管生成因子（血管内皮生长因子 [VEGF]、转化生长因子β1 [TGF-β1]、肝细胞生长因子 [HGF]、碱性成纤维细胞生长因子 [bFGF]、肿瘤坏死因子α [TNF-α]、可溶性血管内皮生长因子受体 1 [sVEGF-R1]、可溶性血管内皮生长因子受体 2 [sVEGF-R2]）在系统性红斑狼疮（SLE）女性患者血清中的浓度，分析其与应用治疗之间的关系。48 例女性 SLE 患者（37 例长期治疗+11 例新诊断）纳入实验组，24 名健康女性纳入对照组。结果显示，新诊断 SLE 患者血清 sVEGF-R2 水平显著升高，sVEGF-R1 水平显著降低。与对照组相比，长期治疗亚组和新诊断 SLE 患者治疗 3 个月后亚组的血清血管生成因子均无显著差异，新诊断 SLE 患者治疗前和治疗 3 个月后亚组也无显著差异。与新诊断未经治疗的 SLE 患者相比，长期治疗的患者血清 sVEGF-R2 水平显著降低。血清 sVEGF-R1 浓度与其他细胞因子水平之间的相关性分析显示，在所有患者中，sVEGF-R1 浓度与 VEGF 和 TNF-α浓度呈正相关。在新诊断未经治疗的亚组中，sVEGF-R1 浓度与 bFGF 浓度之间存在强烈的正相关。此外，在长期治疗的患者中，sVEGF-R1 浓度与 VEGF 水平之间也存在中度正相关。在该亚组中还观察到 sVEGF-R2 与 HGF 之间的相关性。综上所述，进一步的研究确定血管生成因子在 SLE 发病机制和治疗中的重要性是必要的。
