Morrison J M
Fam Pract. 1990 Dec;7(4):253-7. doi: 10.1093/fampra/7.4.253.
A search of the records of one general practice, serving 5282 patients, generated a list of 72 patients (1.36%) who had been using a benzodiazepine tranquillizer continuously for more than 6 months. These patients were interviewed and asked to discontinue the use of these drugs with the help of their general practitioner. An individual approach for each patient was agreed between the general practitioner and the patient. Patients who initially did not agree to try to stop the drug were included in the study. After 1 year, 27 (37.5%) of the patients had stopped using the benzodiazepine completely and 24 (33.3%) had reduced their previous consumption by more than 50%. This outcome was independent of sex, age, drug used, duration of use, whether they were exceeding the original dose of the drug and attendance at a consultant psychiatric clinic. It was significantly more likely that the patient would stop taking the drug if they originally wished to do so, but several of those who initially did not want to try to stop were able to do this. The excess number of consultations for the patients in the study for the year of the study compared with the year before the study only constituted 0.35% of the total number of consultations in the practice. The results were better than expected and the exercise was felt to be worthwhile, particularly as the increase in workload was very small.
对一家服务5282名患者的普通诊所的记录进行检索，列出了72名（1.36%）连续使用苯二氮䓬类镇静剂超过6个月的患者。对这些患者进行了访谈，并要求他们在全科医生的帮助下停止使用这些药物。全科医生和患者就针对每位患者的个性化方法达成了一致。最初不同意尝试停药的患者也被纳入了研究。1年后，27名（37.5%）患者完全停止使用苯二氮䓬类药物，24名（33.3%）患者将之前的用药量减少了50%以上。这一结果与性别、年龄、使用的药物、用药时长、是否超过药物原剂量以及是否就诊于精神科门诊无关。如果患者最初就希望停药，那么他们停药的可能性要大得多，但一些最初不想尝试停药的患者也成功做到了。与研究前一年相比，研究当年参与研究的患者额外的门诊次数仅占该诊所总门诊次数的0.35%。结果比预期的要好，而且大家认为这项工作是值得的，特别是因为工作量的增加非常小。
