mTOR signaling in epileptogenesis: too much of a good thing?

作者信息

Cao Ruifeng, Li Aiqing, Cho Hee-Yeon

机构信息

Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA.

出版信息

J Neurosci. 2009 Oct 7;29(40):12372-3. doi: 10.1523/JNEUROSCI.3486-09.2009.

DOI:10.1523/JNEUROSCI.3486-09.2009

PMID:19812312

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6665095/

Abstract

摘要

相似文献

mTOR signaling in epileptogenesis: too much of a good thing?

J Neurosci. 2009 Oct 7;29(40):12372-3. doi: 10.1523/JNEUROSCI.3486-09.2009.

Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator.

Mol Med. 2023 Oct 25;29(1):142. doi: 10.1186/s10020-023-00742-2.

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.

J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.

Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway.

Biomed Pharmacother. 2016 Jul;81:281-287. doi: 10.1016/j.biopha.2016.04.012. Epub 2016 Apr 22.

Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury.

Sci Rep. 2016 Aug 26;6:32095. doi: 10.1038/srep32095.

Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?

Cell Cycle. 2010 Jun 15;9(12):2281-5. doi: 10.4161/cc.9.12.11866.

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies.

Epilepsia. 2010 Jan;51(1):27-36. doi: 10.1111/j.1528-1167.2009.02341.x. Epub 2009 Oct 8.

mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy.

Neurobiol Dis. 2016 Jan;85:144-154. doi: 10.1016/j.nbd.2015.10.001. Epub 2015 Oct 13.

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway.

Mol Med Rep. 2013 Oct;8(4):1011-6. doi: 10.3892/mmr.2013.1628. Epub 2013 Aug 13.

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.

Neurobiol Dis. 2010 Oct;40(1):193-9. doi: 10.1016/j.nbd.2010.05.024. Epub 2010 May 26.

引用本文的文献

Biological Timing and Neurodevelopmental Disorders: A Role for Circadian Dysfunction in Autism Spectrum Disorders.

Front Neurosci. 2021 Mar 12;15:642745. doi: 10.3389/fnins.2021.642745. eCollection 2021.

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Neuron. 2019 Nov 20;104(4):724-735.e6. doi: 10.1016/j.neuron.2019.08.007. Epub 2019 Sep 12.

Emerging Role of the Nucleolar Stress Response in Autophagy.

Front Cell Neurosci. 2019 Apr 30;13:156. doi: 10.3389/fncel.2019.00156. eCollection 2019.

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3296-E3304. doi: 10.1073/pnas.1721578115. Epub 2018 Mar 19.

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature.

J Neurosci. 2014 Jun 4;34(23):7988-98. doi: 10.1523/JNEUROSCI.0777-14.2014.

Autophagy: regulation and role in development.

Autophagy. 2013 Jul;9(7):951-72. doi: 10.4161/auto.24273.

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling.

Neuron. 2013 Aug 21;79(4):712-24. doi: 10.1016/j.neuron.2013.06.026.

Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis.

J Neurosci. 2012 Nov 7;32(45):15704-14. doi: 10.1523/JNEUROSCI.2392-12.2012.

Epilepsy: Novel therapeutic targets.

J Pharmacol Pharmacother. 2012 Apr;3(2):112-7. doi: 10.4103/0976-500X.95505.

The role of mTOR signaling in Alzheimer disease.

Front Biosci (Schol Ed). 2012 Jan 1;4(3):941-52. doi: 10.2741/s310.

本文引用的文献

Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.

J Neurosci. 2009 Jun 24;29(25):8259-69. doi: 10.1523/JNEUROSCI.4179-08.2009.

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.

J Neurosci. 2009 May 27;29(21):6964-72. doi: 10.1523/JNEUROSCI.0066-09.2009.

Translational control of long-lasting synaptic plasticity and memory.

Neuron. 2009 Jan 15;61(1):10-26. doi: 10.1016/j.neuron.2008.10.055.

Autophagy in neuroprotection and neurodegeneration: A question of balance.

Future Neurol. 2008 May;3(3):309-323. doi: 10.2217/14796708.3.3.309.

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. doi: 10.1073/pnas.0710424105. Epub 2007 Dec 27.

Kainic acid induces early and transient autophagic stress in mouse hippocampus.

Neurosci Lett. 2007 Feb 27;414(1):57-60. doi: 10.1016/j.neulet.2006.12.025. Epub 2006 Dec 27.

Notch signalling regulates stem cell numbers in vitro and in vivo.

Nature. 2006 Aug 17;442(7104):823-6. doi: 10.1038/nature04940. Epub 2006 Jun 25.

Dysregulation of the TSC-mTOR pathway in human disease.

Nat Genet. 2005 Jan;37(1):19-24. doi: 10.1038/ng1494.

Akt-1 expression level regulates CNS precursors.

J Neurosci. 2004 Sep 29;24(39):8531-41. doi: 10.1523/JNEUROSCI.1470-04.2004.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Nat Genet. 2004 Jun;36(6):585-95. doi: 10.1038/ng1362. Epub 2004 May 16.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Suppr
超能文献

mTOR signaling in epileptogenesis: too much of a good thing?

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献

Suppr超能文献

mTOR signaling in epileptogenesis: too much of a good thing?

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献

Suppr
超能文献