Department of Pulmonary Diseases, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
Sleep Breath. 2010 Sep;14(3):241-4. doi: 10.1007/s11325-009-0306-y. Epub 2009 Oct 8.
To evaluate the effect of continuous positive airway pressure (CPAP) therapy on pro-brain natriuretic peptide (BNP) and cardiac markers in patients with obstructive sleep apnea syndrome and normal cardiac function.
Thirty-three consecutive patients with sleep apnea syndrome were analysed for serum pro-BNP and cardiac markers prior to and after 6 months of CPAP therapy.
Twenty five patients had normal (83.3%) while remaining five (16.7%) revealed high pro-BNP values. We did not detect any significant difference between severity of obstructive sleep apnea syndrome and serum pro-BNP levels (p = 0.534). A statistically significant difference was not observed between basal and sixth-month creatine kinase (CK), creatine kinase-MB (CK-MB), troponin I, pro-BNP, aspartate transaminase (AST), and CK levels in patients with sleep apnea syndrome (p > 0.05).
Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro-BNP, CK, CK-MB, troponin I, and AST levels. Markers sensitive to ischemia could be preferred to evaluate effect of obstructive sleep apnea syndrome.
评估持续气道正压通气（CPAP）治疗对心功能正常的阻塞性睡眠呼吸暂停综合征患者脑利钠肽前体（pro-BNP）和心脏标志物的影响。
对 33 例连续的睡眠呼吸暂停综合征患者进行分析，分别在 CPAP 治疗前和治疗后 6 个月检测血清 pro-BNP 和心脏标志物。
25 例患者（83.3%）的 pro-BNP 值正常，而其余 5 例（16.7%）的 pro-BNP 值升高。我们未发现阻塞性睡眠呼吸暂停综合征严重程度与血清 pro-BNP 水平之间存在显著差异（p = 0.534）。在睡眠呼吸暂停综合征患者中，基础值和第 6 个月的肌酸激酶（CK）、肌酸激酶同工酶-MB（CK-MB）、肌钙蛋白 I、pro-BNP、天门冬氨酸转氨酶（AST）和 CK 水平之间未观察到统计学差异（p > 0.05）。
阻塞性睡眠呼吸暂停综合征不会引起心肌损伤，导致血清 pro-BNP、CK、CK-MB、肌钙蛋白 I 和 AST 水平升高。可选择对缺血敏感的标志物来评估阻塞性睡眠呼吸暂停综合征的治疗效果。
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