Positive pressure ventilation treatment reduces plasma levels of amino terminal-pro brain natriuretic peptide in congestive heart failure patients with sleep apnea.

作者信息

Zhao Zhi-Hui, Liu Zhi-Hong, Luo Qin, Xiong Chang-Ming, Ni Xin-Hai, Zhang Jian, Zhang Shu, Yang Yue-Jin

机构信息

Center for Pulmonary Vascular Disease Diagnosis and Treatment, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, PR China.

出版信息

Circ J. 2006 May;70(5):572-4. doi: 10.1253/circj.70.572.

BACKGROUND

The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA).

METHODS AND RESULTS

Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased.

CONCLUSION

Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA.