Translational Brain Tumor Program, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
J Neurooncol. 2010 May;97(3):419-23. doi: 10.1007/s11060-009-0018-y. Epub 2009 Oct 8.
Diffusion-weighted magnetic resonance imaging (DWI) is a sensitive imaging biomarker for tumor cellularity. Functional diffusion maps (fDMs), which examine voxel-by-voxel changes in the apparent diffusion coefficient (ADC) calculated from serial DWIs, have previously been applied to regions of contrast-enhancement; however, application of fDMs to non-enhancing brain tumors has not been pursued. In this case study we demonstrate the utility of applying fDMs to regions of abnormal FLAIR signal intensity in a patient diagnosed with gliomatosis cerebri: a relatively rare, infiltrative, non-enhancing brain tumor. The absolute volume of hypercellularity extracted from fDMs was useful in tracking tumor growth, which correlated in time with a progressive decline in neurological status despite no change in traditional magnetic resonance images. Results of this study demonstrate the value of fDMs, applied to regions of FLAIR abnormal signal intensity, for localizing regions of hypercellularity and for monitoring overall tumor status.
弥散加权磁共振成像（DWI）是一种对肿瘤细胞密度敏感的影像学生物标志物。功能弥散图（fDMs）是通过对一系列 DWI 计算得出的表观扩散系数（ADC）的体素进行逐点分析，可以用来研究增强区域；然而，fDMs 尚未应用于非增强性脑肿瘤。在本病例研究中，我们展示了将 fDMs 应用于脑胶质瘤患者异常 FLAIR 信号强度区域的实用性：脑胶质瘤是一种相对罕见的浸润性非增强性脑肿瘤。从 fDMs 中提取的高细胞密度的绝对体积可用于跟踪肿瘤生长，尽管传统磁共振成像没有变化，但肿瘤生长与神经功能状态的逐渐下降相关。本研究结果表明，fDMs 应用于 FLAIR 异常信号强度区域对于定位高细胞密度区域和监测整体肿瘤状态具有重要价值。
