Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA.
Cardiovasc Res. 2010 Jan 15;85(2):291-302. doi: 10.1093/cvr/cvp333. Epub 2009 Oct 8.
Protein metabolism is a central element of every living cell. The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular proteins. Over the past few years, remarkable progress has been made in our understanding of the role of the UPS in vascular biology and pathobiology, particularly atherosclerosis. This review reflects on the recent developments from the effects on endothelial cells and the initial stage of atherosclerosis to the effects on vascular smooth muscle and the progression stage of atherosclerosis and finally to the effects on cell viability and the complication stage of atherosclerosis. It will conclude with the integration of the available information in a synoptic view of the involvement of the UPS in atherosclerosis.
蛋白质代谢是每个活细胞的核心要素。泛素-蛋白酶体系统（UPS）是蛋白质代谢机制的一个组成部分，介导大多数细胞内蛋白质的转录后加工和降解。在过去的几年中，我们对 UPS 在血管生物学和病理生物学中的作用的理解取得了显著进展，特别是在动脉粥样硬化方面。这篇综述反映了 UPS 在血管生物学中的最新发展，从对内皮细胞和动脉粥样硬化初始阶段的影响，到对血管平滑肌和动脉粥样硬化进展阶段的影响，最后到对细胞活力和动脉粥样硬化并发症阶段的影响。它将综合 UPS 在动脉粥样硬化中的作用的现有信息，以综述的形式进行总结。
