Liang L Z
Tongji Hospital, Tongji Medical College, Wuhan.
Zhonghua Zhong Liu Za Zhi. 1990 Nov;12(6):410-3.
Blood samples from 79 subjects (27 cases of ovarian malignancy, 2 ovarian borderline epithelial tumor, 38 benign gynecologic disease and 12 healthy women) were measured for peripheral blood T-cell subsets using monoclonal antibodies and SPA-Ig rosette technique. It was found that in patients with ovarian malignancy, the percentage of OKT4+ cells was significantly reduced whereas the percentage of OKT8+ cells was markedly increased as compared with those in the healthy women and patients with benign gynecologic disease; OKT4/OKT8 ratio declined obviously; which were more pronounced in patients with advanced or recurrent tumor.
采用单克隆抗体和SPA-Ig花环技术，对79名受试者（27例卵巢恶性肿瘤、2例卵巢交界性上皮肿瘤、38例良性妇科疾病患者及12名健康女性）的血样进行外周血T细胞亚群检测。结果发现，与健康女性及良性妇科疾病患者相比，卵巢恶性肿瘤患者OKT4+细胞百分比显著降低，而OKT8+细胞百分比显著升高；OKT4/OKT8比值明显下降；在肿瘤晚期或复发患者中更为明显。
