Juárez A, Parés R, Vives J
Rev Esp Fisiol. 1977 Sep;33(3):217-20.
Specific activity of glutamate dehydrogenase (GD) and glutamate synthase (GtS) has been determined in the wild strain C3 and on a non excreting pro- mutant strain. Methionine sulfone shows inhibitory effects on their growth. The addition of alpha-ketoglutarate to the medium prevents the inhibitory effect and increases the GtS specific activity in both strains. The physiological effect of methionine sulfone and its suppression by alpha-ketoglutarate is discussed.
已测定野生型菌株C3和非分泌型原突变菌株中谷氨酸脱氢酶(GD)和谷氨酸合酶(GtS)的比活性。甲砜霉素对它们的生长有抑制作用。向培养基中添加α-酮戊二酸可防止这种抑制作用,并增加两种菌株中的GtS比活性。本文讨论了甲砜霉素的生理效应及其被α-酮戊二酸抑制的情况。