抗肿瘤坏死因子治疗与类风湿关节炎中的 B 细胞。
Anti-tumour necrosis factor therapy and B cells in rheumatoid arthritis.
出版信息
Arthritis Res Ther. 2009;11(5):128. doi: 10.1186/ar2809. Epub 2009 Oct 6.
Abstract
The efficacy of B-cell depletion therapy in rheumatoid arthritis (RA) has led to a renewed interest in B cells and their products and the role they play in the pathogenesis of the disease. Agents blocking tumour necrosis factor (TNF) are also very effective in the treatment of RA. It has long been known that the use of anti-TNF therapy can be associated with development of anti-nuclear and anti-double-stranded DNA antibodies and, more rarely, a lupus-like syndrome. Recently, studies have been published investigating further possible effects of anti-TNF agents on B cells and whether these could contribute to their effectiveness in RA.
摘要
B 细胞耗竭疗法在类风湿关节炎（RA）中的疗效，使人们对 B 细胞及其产物重新产生了兴趣，以及它们在疾病发病机制中的作用。阻断肿瘤坏死因子（TNF）的药物在 RA 的治疗中也非常有效。长期以来，人们一直知道，使用抗 TNF 治疗可能与抗核和抗双链 DNA 抗体的发展有关，而且更罕见的是，出现狼疮样综合征。最近，发表了一些研究，进一步研究了抗 TNF 药物对 B 细胞的可能影响，以及这些影响是否有助于它们在 RA 中的疗效。
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