用于复杂性抑郁症的新型药物。

Newer medications for complicated depression.

作者信息

Thase Michael E

机构信息

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, and Pittsburgh Medical Center, Pittsburgh, PA, USA.

出版信息

J Clin Psychiatry. 2009 Sep;70(9):e33. doi: 10.4088/JCP.8001tx12c.

DOI:10.4088/JCP.8001tx12c

PMID:19818239

Abstract

Available antidepressant medications are safe and moderately effective for most patients, but their overall efficacy is similar and underwhelming. The most recently developed antidepressants are either stereoisomers or metabolites of older drugs or belong to an existing class of antidepressants. The development of new medications with novel mechanisms of action and increased efficacy is needed to address unmet needs in the pharmacotherapy of depression.

摘要

现有的抗抑郁药物对大多数患者来说是安全且有一定疗效的，但它们的总体疗效相似且效果不佳。最新研发的抗抑郁药物要么是旧药的立体异构体或代谢产物，要么属于现有的抗抑郁药物类别。需要研发具有新作用机制和更高疗效的新药物，以满足抑郁症药物治疗中未得到满足的需求。