Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
J Biomech. 2010 Jan 5;43(1):166-75. doi: 10.1016/j.jbiomech.2009.09.022. Epub 2009 Oct 9.
Collagen is the main load bearing protein in many soft tissues, and in cardiovascular tissues in particular. In many tissues collagen has a specific architecture that is crucial for the biomechanical function of the tissue. Typical examples are the hammock-shaped collagen architecture in heart valves and a helical pattern in arteries. One of the objectives in cardiovascular tissue engineering is the reconstitution of this architecture. It is hypothesized that the architecture is mediated by mechanical stimulation. Computational models were developed to predict the mechanoregulation of the collagen architecture. This review recapitulates the key modeling assumptions and results achieved to date.
胶原蛋白是许多软组织，尤其是心血管组织中的主要承重蛋白。在许多组织中，胶原蛋白具有特定的结构，这对于组织的生物力学功能至关重要。典型的例子是心脏瓣膜中的吊床状胶原蛋白结构和动脉中的螺旋图案。心血管组织工程的目标之一是重建这种结构。据推测，这种结构是由机械刺激介导的。已经开发了计算模型来预测胶原蛋白结构的机械调节。这篇综述总结了迄今为止取得的关键建模假设和结果。
