Katada T, Ui M
Endocrinology. 1977 Oct;101(4):1247-55. doi: 10.1210/endo-101-4-1247.
In order to study the mechanism by which pertussis-sensitized rats showed enhanced insulin secretory responses to various secretagogues (Sumi, T., and M. Ui, Endocrinology 97: 352, 1975), pancreases of rats receiving a single injection of Bordetella pertussis cells 3 days before were perfused with Krebs-Ringer solution, and release of insulin therefrom was compared with that from the pancreases of normal rats. Much more insulin was released from the pancreas of the pertussis-sensitized rat than from the pancreas of the normal rat in response to glucose, arginine, glibenclamide and 3-isobuty-l-methylxanthine. The inhibition of insulin secretion caused by epinephrine, norepinephrine or phenylephrine via alpha-adrenergic receptors in the pancreas of normal rats was no longer observable with the pancreas from pertussis-sensitized rats. Instead, the addition of epinephrine with or without phentolamine gave rise to a marked secretion of insulin from the pancreas of pertussis-sensitized rats which was prevented by propranolol. It is concluded that a single injection of B. pertussis into rats results in a sustained modification of insulin secretory processes in the pancreatic beta-cells in such a manner as to favor insulin secretory responses to beta-adrenergic stimulation and other secretagogues.
为了研究百日咳致敏大鼠对各种促分泌剂表现出增强的胰岛素分泌反应的机制（Sumi，T.，和M. Ui，《内分泌学》97：352，1975），对3天前单次注射百日咳博德特氏菌细胞的大鼠的胰腺用 Krebs-Ringer 溶液进行灌注，并将其胰岛素释放量与正常大鼠胰腺的胰岛素释放量进行比较。与正常大鼠胰腺相比，百日咳致敏大鼠胰腺在对葡萄糖、精氨酸、格列本脲和3-异丁基-1-甲基黄嘌呤的反应中释放出更多的胰岛素。正常大鼠胰腺中由肾上腺素、去甲肾上腺素或苯肾上腺素通过α-肾上腺素能受体引起的胰岛素分泌抑制在百日咳致敏大鼠的胰腺中不再可见。相反，添加肾上腺素（无论有无酚妥拉明）都会导致百日咳致敏大鼠胰腺显著分泌胰岛素，而普萘洛尔可阻止这种分泌。得出的结论是，给大鼠单次注射百日咳博德特氏菌会导致胰腺β细胞中胰岛素分泌过程的持续改变，从而有利于胰岛素对β-肾上腺素能刺激和其他促分泌剂的分泌反应。
