Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
J Mol Histol. 2009 Jun;40(3):209-15. doi: 10.1007/s10735-009-9232-3. Epub 2009 Oct 11.
Heme oxygenase (HO)/carbon monoxide (CO) and nitric oxide synthase (NOS)/nitric oxide (NO) systems are involved in sensory information processing. The present study was undertaken to examine the distribution of HO-2 and NOS in the spinal trigeminal nucleus (STN) of the rat, using histochemistry and immunohistochemistry. Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining was found that NADPH-d activity was more prominent in the nucleus caudalis (Vc) and the dorsomedial subdivision of the nucleus oralis (Vo) than in other spinal trigeminal regions. Immunohistochemistry for HO-2 revealed that HO-2 staining neurons distributed extensively, which intensity was higher in the rostral than caudal part of the STN. The colocalization of NADPH-d and HO-2 was mainly confined in the Vc. The expression and distribution of NADPH-d and HO-2 suggest that NO and CO are likely neurotransmitters and might function in the processing orofacial signal in the STN together.
血红素加氧酶（HO）/一氧化碳（CO）和一氧化氮合酶（NOS）/一氧化氮（NO）系统参与感觉信息处理。本研究采用组织化学和免疫组织化学方法，研究了 HO-2 和 NOS 在大鼠三叉神经脊核（STN）中的分布。发现烟酰胺腺嘌呤二核苷酸磷酸-黄递酶（NADPH-d）染色 NADPH-d 活性在尾核（Vc）和口腔核背内侧亚区（Vo）比其他三叉神经区更为明显。HO-2 的免疫组织化学显示 HO-2 染色神经元广泛分布，在 STN 的前部分比后部分强度更高。NADPH-d 和 HO-2 的共定位主要局限于 Vc。NADPH-d 和 HO-2 的表达和分布表明，NO 和 CO 可能是神经递质，可能共同作用于 STN 中口腔信号的处理。
