Arimori K, Hashimoto Y, Nakano M
Department of Pharmacy, Kumamoto University Hospital, Honjo, Japan.
J Pharm Pharmacol. 1990 Oct;42(10):726-8. doi: 10.1111/j.2042-7158.1990.tb06569.x.
Intestinal dialysis of drugs by oral administration of activated charcoal has been compared with peritoneal dialysis in rats. The average amounts of theophylline transported over 120 min into the intestinal lumen and the peritoneal cavity were 15.7 and 16.5% of the intravenous dose (10 mg kg-1), respectively, showing no significant difference, whereas the amount of the same intravenous dose of phenobarbitone transported from the blood into the intestinal lumen (7.8%) was significantly smaller than that entering the peritoneal cavity (12.5%). The net water flux showed that secretion predominated in the peritoneal transport whilst absorption predominated in the intestinal transport for both drugs. However, the net water flux in the intestinal lumen after intravenous theophylline (as aminophylline) was significantly smaller than that following phenobarbitone. The differences in transport across the two membranes could be due to differences in the intrinsic properties of the could be due to differences in the intrinsic properties of the membranes, such as the surface area, the thickness of the membrane and the distribution of blood vessels. Differences could also be due to differences in the pharmacological effects of the drugs.
通过给大鼠口服活性炭进行药物肠道透析，并与腹膜透析进行了比较。在120分钟内，茶碱转运至肠腔和腹膜腔的平均量分别为静脉注射剂量（10毫克/千克）的15.7%和16.5%，无显著差异，而相同静脉注射剂量的苯巴比妥从血液转运至肠腔的量（7.8%）显著小于进入腹膜腔的量（12.5%）。净水流显示，两种药物在腹膜转运中以分泌为主，而在肠道转运中以吸收为主。然而，静脉注射茶碱（以氨茶碱形式）后肠腔内的净水流显著小于注射苯巴比妥后的净水流。跨两种膜转运的差异可能是由于膜的内在特性不同，如表面积、膜厚度和血管分布。差异也可能是由于药物的药理作用不同。
