佐匹克隆过量导致的溶血性贫血。
Hemolytic anemia after zopiclone overdose.
作者信息
Fung Hin Tat Jeffrey, Lai Cing Hon, Wong Oi Fung, Lam Shing Kit Tommy, Lam Ka Keung
机构信息
Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China.
出版信息
Clin Toxicol (Phila). 2009 Nov;47(9):902-3. doi: 10.3109/15563650903313541.
INTRODUCTION
Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis.
CASE
A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis.
DISCUSSION
In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
引言
佐匹克隆与高铁血红蛋白血症有关。我们报告一例佐匹克隆过量导致的另一种血液学并发症——溶血的病例。
病例
一名46岁女性过量服用了50至100片7.5毫克的佐匹克隆。贫血、咬痕红细胞、未结合胆红素和乳酸脱氢酶升高、触珠蛋白降低以及网织红细胞增多表明存在氧化性溶血。
讨论
在佐匹克隆过量的情况下，可能会出现氧化应激，不仅会导致高铁血红蛋白血症，还会引发溶血。
Zotero 插件