Han J Y, Choi J S, Chun J M, Park H D, Lee S Y, Kim C H, Park Q, Nava-Ocampo A A, Koren G
Korean Motherisk Program, Department of Obstetrics and Gynecology, Cheil Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
J Obstet Gynaecol. 2009 Nov;29(8):694-7. doi: 10.3109/01443610903177128.
We assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-contaminated blood products in South Korea. A total of 18 women matched to cases by age, gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products not contaminated with acitretin, was also recruited. There were nine babies born in the case group. No differences (p > 0.05) were observed between cases and controls in the gestational age at delivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/- 568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g) (33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born in either group. In conclusion, inadvertent exposure to acitretin-contaminated blood products was not associated with adverse pregnancy outcomes, probably because of the removal of acitretin and etretinate during the manufacturing process of blood products.
我们评估了韩国9名意外输注了被阿维A污染血液制品的女性的妊娠结局。另外招募了18名在年龄、妊娠次数以及单胎或双胎妊娠情况上与病例组匹配，且输注了未被阿维A污染血液制品的女性。病例组中有9名婴儿出生。病例组和对照组在分娩孕周（38.3±1.6周 vs 37.8±2.2周）、出生体重（3146±874克 vs 3106±568克）、早产率（22.2% vs 11.1%）以及低出生体重率（<2500克）（33.3% vs 16.7%）方面均未观察到差异（p>0.05）。两组均未出现畸形或神经异常的病例。总之，意外接触被阿维A污染的血液制品与不良妊娠结局无关，这可能是因为在血液制品的制造过程中阿维A和维甲酸已被去除。
