Bányai Krisztián, Gentsch Jon R, Martella Vito, Bogdán Agnes, Havasi Viktória, Kisfali Péter, Szabó Alíz, Mihály Ilona, Molnár Péter, Melegh Béla, Szücs György
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Hungarian Academy of Sciences, Budapest, Hungary.
J Infect Dis. 2009 Nov 1;200 Suppl 1:S222-7. doi: 10.1086/605052.
Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents.
在16年期间，通过对表面抗原进行测序和系统发育分析，在匈牙利研究了全球最常见的轮状病毒基因型G1P[8]的流行病学趋势。在6个季节中观察到了流行病学主要G1P[8]毒株之间的抗原转变，这由G1 VP7和P[8] VP4基因亚系的变化表明。研究人群中一些轮状病毒VP4和VP7基因亚系的时间聚类以及先前未识别的轮状病毒亚系的周期性出现和/或复苏表明这些常见毒株具有动态性质。最近建立的国际毒株监测网络可能有助于识别和追踪具有重要流行病学意义的轮状病毒毒株在国家和各大洲之间的传播。
