Institute for Medical Informatics and Biostatistics, Basel, Switzerland.
Diabetes Technol Ther. 2009 Oct;11(10):623-33. doi: 10.1089/dia.2009.0043.
There is a growing body of evidence that the sole use of hemoglobin A1c is insufficient to adequately reflect the metabolic situation of patients with diabetes mellitus. The risk of developing diabetes-related complications apparently not only depends on the long-term stability of glucose values, but also on the presence or occurrence of short-term glycemic peaks and nadirs lasting for minutes or hours during a day. This leads to the phenomenon of glycemic variability. This article reviews the existing evidence for the clinical relevance of short-term glucose variations and the currently available different means of measuring glycemic variability.
越来越多的证据表明，单独使用糖化血红蛋白（HbA1c）不足以充分反映糖尿病患者的代谢情况。发生糖尿病相关并发症的风险显然不仅取决于血糖值的长期稳定性，还取决于在一天中几分钟或几小时内持续出现的短期血糖峰值和低谷。这导致了血糖变异性的现象。本文回顾了短期血糖变化的临床相关性以及目前可用的不同测量血糖变异性的方法的现有证据。
