Department of Gastroenterology and Hepatology, St George's Healthcare NHS Trust, London, UK.
Aliment Pharmacol Ther. 2010 Jan 15;31(2):247-52. doi: 10.1111/j.1365-2036.2009.04168.x. Epub 2009 Oct 12.
Hereditary haemochromatosis is a preventable cause of liver disease with an increasing disease burden.
To investigate time trends for hospital admission ascribed to haemochromatosis in England during the period from 1989/1990 to 2002/2003 and mortality from 1979 to 2005.
Hospital admission data, relating to both in-patients and day-cases, were obtained from the Hospital Episodes Statistics service. Mortality rates for England and Wales were provided by the Office for National Statistics.
Haemochromatosis is an uncommon cause for hospital admission. Age-standardized in-patient admission rates increased over the study period by 269% in men and by 290% in women: (from 0.64 to 2.36 and from 0.21 to 0.81 per year per 100 000). The increase in age-standardized day-case admission rates was even higher (men: from 2.78 to 34.9 per year per 100 000, 1155%; women: from 0.58 to 11.67 per year per 100 000, 1924%). Haemochromatosis was recorded as an uncommon cause of death.
Hospital in-patient and day case admissions for haemochromatosis increased markedly over the study period while mortality remained low. Both admission rates and mortality were higher in men than in women. The increase in admission rate may reflect improved recognition and diagnosis of iron overload disorders following identification of the HFE gene.
遗传性血色素沉着症是一种可预防的肝病病因，其疾病负担不断增加。
调查 1989/1990 年至 2002/2003 年期间英国因血色素沉着症住院的时间趋势和 1979 年至 2005 年的死亡率。
从医院发病统计服务中获得了与住院和日间病例相关的住院数据。英格兰和威尔士的死亡率由国家统计局提供。
血色素沉着症是住院的罕见病因。在研究期间，男性的年龄标准化住院入院率增加了 269%，女性增加了 290%：（从每年每 10 万人 0.64 到 2.36 和从每年每 10 万人 0.21 到 0.81）。年龄标准化日间病例入院率的增加甚至更高（男性：从每年每 10 万人 2.78 到 34.9，增加了 1155%；女性：从每年每 10 万人 0.58 到 11.67，增加了 1924%）。血色素沉着症被记录为一种罕见的死亡原因。
在研究期间，因血色素沉着症住院的患者数量明显增加，而死亡率仍然较低。男性的入院率和死亡率均高于女性。入院率的增加可能反映了 HFE 基因鉴定后对铁过载疾病的认识和诊断有所提高。
