Gebhardt Constance, Hirschberger Johannes, Rau Stefanie, Arndt Gisela, Krainer Karen, Schweigert Florian J, Brunnberg Leo, Kaspers Bernd, Kohn Barbara
Small Animal Clinic, Freie Universität Berlin, Berlin, Germany.
J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):450-8. doi: 10.1111/j.1476-4431.2009.00462.x.
There is a high mortality rate in patients with systemic inflammatory response syndrome (SIRS) or sepsis. Therefore, an early diagnosis and prognostic assessment is important for optimal therapeutic intervention. The objective of the study was to evaluate if baseline values and changes in serum C-reactive protein (CRP) might predict survival in dogs with SIRS and sepsis.
Prospective study; July 2004 to July 2005.
Small Animal Clinic, Berlin, Clinic of Small Animal Medicine, Munich.
Sixty-one dogs.
For the CRP analysis blood was drawn on day 0, 1, and 2; CRP was measured using a commercial ELISA test kit. Thirteen dogs suffered from nonseptic SIRS and 48 dogs from sepsis. The 14-day survival rate was 61% (69% nonseptic SIRS, 58% sepsis). Serum CRP was higher in sick dogs compared with controls (P<0.001). Over the 3-day period surviving dogs (n=31) displayed a significantly greater decrease in CRP than nonsurvivors (n=10) (P=0.001). No correlation was found between the initial CRP concentrations and the survival rate. The changes in CRP corresponded to the survival rate (P=0.01).
There was no significant relationship between the survival rate in dogs with nonseptic SIRS or sepsis and the initial serum CRP concentrations. There was a correlation between decreasing CRP concentrations and recovery from disease. However, the changes in CRP concentrations over a 3-day period correctly predicted survival in 94% of dogs and death in 30% of the dogs (false positive rate 22%).
全身炎症反应综合征（SIRS）或脓毒症患者的死亡率很高。因此，早期诊断和预后评估对于最佳治疗干预至关重要。本研究的目的是评估血清C反应蛋白（CRP）的基线值和变化是否可以预测患有SIRS和脓毒症的犬的存活率。
前瞻性研究；2004年7月至2005年7月。
柏林小动物诊所，慕尼黑小动物医学诊所。
61只犬。
为进行CRP分析，在第0、1和2天采集血液；使用商用ELISA检测试剂盒测量CRP。13只犬患有非脓毒症性SIRS，48只犬患有脓毒症。14天存活率为61%（非脓毒症性SIRS为69%，脓毒症为58%）。患病犬的血清CRP高于对照组（P<0.001）。在3天期间，存活犬（n=31）的CRP下降幅度明显大于非存活犬（n=10）（P=0.001）。初始CRP浓度与存活率之间未发现相关性。CRP的变化与存活率相对应（P=0.01）。
非脓毒症性SIRS或脓毒症犬的存活率与初始血清CRP浓度之间无显著关系。CRP浓度降低与疾病恢复之间存在相关性。然而，3天内CRP浓度的变化正确预测了94%犬的存活和30%犬的死亡（假阳性率22%）。
