Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany.
Clin Exp Rheumatol. 2009 Jul-Aug;27(4 Suppl 55):S131-8.
In terms of adult-onset definitions, rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are rarely diagnosed in children. Adult RA is in most aspects similar to seropositive polyarticular arthritis in children, but AS differs in its clinical presentation according to age at onset. In general, the nomenclature and classifications of arthritis in children encompass subgroups with specific signs or laboratory tests and pathogenic mechanisms that distinguish one clinical form from the other. While one of these subgroups corresponds to RA, the one related to AS usually includes children with undifferentiated SpA and not definite AS. Thus, comparisons of RA and AS in children actually correspond to comparisons of various forms of childhood arthritis, currently classified as juvenile idiopathic arthritis (JIA) and AS in its early undifferentiated form. In this paper, we review these to finally compare the two populations.
在成人发病定义方面，类风湿关节炎（RA）和强直性脊柱炎（AS）很少在儿童中诊断。成人 RA 在大多数方面与儿童血清阳性多关节炎相似，但 AS 根据发病年龄在临床表现上有所不同。一般来说，儿童关节炎的命名和分类包括具有特定体征或实验室检查和发病机制的亚组，这些亚组将一种临床形式与另一种区分开来。虽然其中一个亚组对应 RA，但与 AS 相关的亚组通常包括未分化的 SpA 而不是明确的 AS 患儿。因此，儿童 RA 和 AS 的比较实际上对应于目前分类为幼年特发性关节炎（JIA）和早期未分化形式的 AS 的各种儿童关节炎形式的比较。在本文中，我们将对这些进行综述，最终对这两种人群进行比较。
