Telegdy G, Kardos M
Acta Physiol Acad Sci Hung. 1975;46(3):253-6.
5-hydroxytryptamine at a concentration of 0.04 microgram/ml was able to block the ACTH release caused by hypothalamic tissue (CRF) while it was ineffective when a hypothalamic extract containing CRF was used. 5-hydroxytryptophan added to rat adrenal tissue caused a dose-dependent increase in corticosterone production. In a dose of 0.04 microgram/ml, 0.4 microgram/ml and 4.0 microgram/ml, 5-hydroxytryptophan was able to inhibit the ACTH release caused by hypothalamic tissue in vitro. However 0.04 microgram/ml was ineffective on the increase in ACTH secretion elicited by hypothalamic extract CRF. The data suggest that the inhibitory action of 5-hydroxytryptophan and 5-hydroxytryptamine is exerted at the hypothalamic level by inhibiting the release and/or synthesis of the corticotrophic releasing factor.
浓度为0.04微克/毫升的5-羟色胺能够阻断下丘脑组织（促肾上腺皮质激素释放因子）引起的促肾上腺皮质激素释放，而当使用含有促肾上腺皮质激素释放因子的下丘脑提取物时则无效。添加到大鼠肾上腺组织中的5-羟色氨酸导致皮质酮生成呈剂量依赖性增加。在0.04微克/毫升、0.4微克/毫升和4.0微克/毫升的剂量下，5-羟色氨酸能够在体外抑制下丘脑组织引起的促肾上腺皮质激素释放。然而，0.04微克/毫升对下丘脑提取物促肾上腺皮质激素释放因子引起的促肾上腺皮质激素分泌增加无效。数据表明，5-羟色氨酸和5-羟色胺的抑制作用是通过抑制促肾上腺皮质激素释放因子的释放和/或合成在下丘脑水平发挥的。
