Departament de Psicologia Clínica i de la Salut, Facultat de Psicologia, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain.
Schizophr Res. 2009 Dec;115(2-3):303-9. doi: 10.1016/j.schres.2009.09.021. Epub 2009 Oct 12.
Personality traits such as neuroticism are associated with schizophrenia and schizotypy. However, studies thus far have not clarified the differential association of neuroticism with individual schizotypy dimensions and the role it plays in the expression of schizophrenia-spectrum psychopathology. 204 nonclinically ascertained participants completed self-report questionnaires assessing neuroticism and the positive and negative schizotypy dimensions, and underwent structured interviews assessing schizophrenia-spectrum psychopathology (psychotic-like experiences, negative symptoms, cluster A personality disorders and traits), mood episodes, substance abuse, and global functioning. Results indicated that neuroticism predicted positive symptoms of schizophrenia and depression, over-and-above the effects of both schizotypy dimensions. Also, neuroticism moderated the association of positive schizotypy with interview measures of psychopathology and functioning. The results of this study are consistent with other research indicating that neuroticism is etiologically relevant for schizophrenia-spectrum psychopathology and that it cannot be considered solely a 'secondary effect' of spectrum disorders. Current psychological models of psychosis can accomodate the finding of neuroticism being a shared vulnerability factor for affective and psychotic disorders.
人格特质，如神经质，与精神分裂症和精神分裂样特质有关。然而，迄今为止的研究还没有阐明神经质与个体精神分裂样特质维度的差异关联，以及它在精神分裂症谱系精神病理学表现中的作用。204 名非临床确定的参与者完成了自我报告问卷，评估神经质和正性及负性精神分裂样特质维度，并接受了评估精神分裂症谱系精神病理学（类精神病体验、阴性症状、A 类人格障碍和特质）、心境发作、物质滥用和总体功能的结构访谈。结果表明，神经质预测了精神分裂症和抑郁的阳性症状，超过了两个精神分裂样特质维度的影响。此外，神经质调节了正性精神分裂样特质与精神病理学和功能的访谈测量之间的关联。这项研究的结果与其他研究一致，表明神经质与精神分裂症谱系精神病理学有病因学上的关联，不能仅仅将其视为谱系障碍的“次要效应”。目前的精神病心理学模型可以容纳神经质是情感和精神病障碍的共同脆弱性因素的发现。
