Dehennaut Vanessa, Leprince Dominique
CNRS-UMR 8161, Institut de Biologie de Lille, Université de Lille-Nord de France, Institut Pasteur de Lille, IFR 142, 1, rue Calmette, BP447, 59017, Lille Cedex, France.
Bull Cancer. 2009 Nov;96(11):E66-72. doi: 10.1684/bdc.2009.0959.
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.
HIC1（癌症中高甲基化1）是一种肿瘤抑制基因，在许多人类癌症中通过表观遗传机制失活。HIC1编码一种转录抑制因子，该抑制因子包含一个N端BTB/POZ结构域和一个C端DNA结合结构域，后者含有五个Krüppel样C(2)H(2)锌指。迄今为止，已知的HIC1靶基因很少，HIC1活性的调控也尚未完全阐明。然而，本综述总结的越来越多的研究有力地表明，HIC1通过建立涉及HIC1、p53、SIRT1和E2F1的几个复杂调控环，在DNA损伤反应中发挥核心作用。
