免疫沉默的癌症克隆从母亲传给后代。
Immunologically silent cancer clone transmission from mother to offspring.
作者信息
Isoda Takeshi, Ford Anthony M, Tomizawa Daisuke, van Delft Frederik W, De Castro David Gonzalez, Mitsuiki Norkio, Score Joannah, Taki Tomohiko, Morio Tomohiro, Takagi Masatoshi, Saji Hiroh, Greaves Mel, Mizutani Shuki
机构信息
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan.
出版信息
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17882-5. doi: 10.1073/pnas.0904658106. Epub 2009 Oct 12.
Abstract
Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally-derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.
摘要
在过去的100年里，曾有罕见的癌症母婴传播病例记录，但关于共享癌症克隆体的证据一直非常有限。我们提供了白血病细胞克隆体在子宫内由母亲传给后代的遗传学证据。母婴癌症克隆体共享相同的独特BCR-ABL1基因组融合序列，表明它们有共同的单细胞起源。婴儿癌症中的微卫星标记均来自母亲。此外，婴儿体内源自母亲的癌细胞在6号染色体短臂的一个拷贝上有一个主要缺失，其中包括婴儿未遗传的HLA等位基因的缺失（即对婴儿来说是外来的），这提示了一种可能的免疫逃逸机制。
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