新型抗高血压化合物奈必洛尔的合成及药理性质
Synthesis and pharmacological properties of nebivolol, a new antihypertensive compound.
作者信息
Van Lommen G, De Bruyn M, Schroven M
机构信息
Janssen Research Foundation, Synthetic Department, Beerse, Belgium.
出版信息
J Pharm Belg. 1990 Nov-Dec;45(6):355-60.
PMID:1982295
Abstract
The synthesis of alpha,alpha' (iminobis(methylene]-bis-(3,4-dihydro-2H-1benzopyran-2-metha nol) derivatives and the stereochemistry and pharmacological profile of this new class of antihypertensive compounds are described. Finally, the selection and pharmacological profile of the preferred compound of this series, nebivolol and its enantiomers, is discussed.
摘要
描述了α,α'（亚氨基双（亚甲基）]-双-（3,4-二氢-2H-1-苯并吡喃-2-甲醇）衍生物的合成以及这类新型抗高血压化合物的立体化学和药理特性。最后，讨论了该系列首选化合物奈必洛尔及其对映体的选择和药理特性。
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