使用乙烯基三氟硼酸钾合成2-取代的2H-色烯
Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates.
作者信息
Liu Fei, Evans Todd, Das Bhaskar C
机构信息
Department of Nuclear Medicine Albert Einstein College of Medicine, Bronx, NY 10461, United States.
出版信息
Tetrahedron Lett. 2008 Mar 3;49(10):1578-1581. doi: 10.1016/j.tetlet.2008.01.008.
Abstract
2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.
摘要
在仲胺存在下，使用乙烯基硼酸酯钾从水杨醛合成了2H-色烯。作为正在进行的开发转化生长因子-β（TGF-β）受体抑制剂项目的一部分，我们合成了这些2H-色烯衍生物。乙烯基三氟硼酸钾在仲胺存在下于80℃与水杨醛反应，以70-90%的产率生成2-取代的2H-色烯衍生物。
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