Laboratoire Angiogenèse Embryonnaire et Pathologique, INSERM U833, France.
Curr Opin Nephrol Hypertens. 2010 Jan;19(1):26-31. doi: 10.1097/MNH.0b013e328332fc13.
Normal development and adult physiology of the kidney and vasculature rely heavily on bone morphogenetic proteins (BMPs). Here we compile evidence that favors the notion that BMPs are also critically involved in the process of generation and maintenance of renal and vascular diseases.
Molecular manipulation of BMP signaling in vivo and in vitro has been instrumental in showing the protective role of BMPs on renal fibrosis and diabetic nephropathy. Similarly, activation of those pathways produces phenotypic changes in vascular smooth muscle and endothelial cells, tightly linked to the pathogenesis of vascular calcification, hypertrophy and atherosclerosis.
Gain-of-function and loss-of-function experiments targeting BMP pathway agonists and inhibitors lead to significant progress in the comprehension of renal and vascular normal and altered behavior. The demonstration that BMP signaling plays an important part in pathological conditions of the vasculature and the kidney opens up possibilities for the development of diagnostic and therapeutic tools.
肾脏和脉管系统的正常发育和成年生理学在很大程度上依赖于骨形态发生蛋白（BMPs）。在这里，我们汇集了支持 BMPs 也严重参与肾脏和血管疾病发生和维持过程的证据。
体内和体外对 BMP 信号转导的分子操作对于显示 BMPs 在肾纤维化和糖尿病肾病中的保护作用至关重要。同样，这些途径的激活会导致血管平滑肌和内皮细胞的表型变化，与血管钙化、肥大和动脉粥样硬化的发病机制密切相关。
针对 BMP 途径激动剂和抑制剂的功能获得和功能丧失实验，在理解肾脏和血管的正常和改变的行为方面取得了重大进展。BMP 信号转导在脉管系统和肾脏病理状况中发挥重要作用的证明为开发诊断和治疗工具开辟了可能性。
