Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands.
FEBS Lett. 2012 Jul 4;586(14):1993-2002. doi: 10.1016/j.febslet.2012.04.030. Epub 2012 May 3.
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that perturbations in BMP signaling lead to various diseases, such as skeletal diseases, vascular diseases and cancer. Mutations in BMP type II receptor and BMP type I receptor/activin receptor-like kinase 1 have been linked to pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, respectively. BMPs have also been implicated in promoting vascular calcification and tumor angiogenesis. In this review we discuss the role of BMP signaling in vascular diseases and the value of BMP signaling as a vascular disease marker or a therapeutic target.
骨形态发生蛋白（BMPs）是转化生长因子-β（TGF-β）家族的成员，通过 I 型和 II 型丝氨酸/苏氨酸激酶受体和细胞内 Smad 转录因子发挥信号作用。BMPs 是发育和组织稳态的多功能调节剂，最初被描述为骨再生的诱导剂。人类和小鼠的遗传研究表明，BMP 信号转导的干扰会导致各种疾病，如骨骼疾病、血管疾病和癌症。BMP II 型受体和 BMP I 型受体/激活素受体样激酶 1 的突变分别与肺动脉高压和遗传性出血性毛细血管扩张症有关。BMPs 也与促进血管钙化和肿瘤血管生成有关。在这篇综述中，我们讨论了 BMP 信号在血管疾病中的作用，以及 BMP 信号作为血管疾病标志物或治疗靶点的价值。
