口服氧化氘对大鼠肝脏的生物学效应。

Biologic effects of orally administered deuterium oxide on rat liver.

作者信息

Kanwar K C, Verma R

出版信息

Exp Pathol (Jena). 1977;13(4-5):255-61. doi: 10.1016/s0014-4908(77)80010-0.

PMID:198233

Abstract

Rats were made to drink D2O mixed water (30: 70) for 6 weeks in order to study the biological effects of orally administered D2O on the liver. Heavy water administration results in gradual decrease in the body weight whereas the liver showed marginal increase in weight throughout the experimental period. Phosphatases and dehydrogenases were analyzed biochemically. Acid phosphatase, glucose-6-phosphatase and adenosine triphosphatase registered fall in contrast to alkaline phosphatase, SDH and LDH, all of which showed a definite increase. Lipids, nucleic acids and proteins, estimated biochemically, gradually decreased throughout the experimental period in response to D2O feeding.

摘要

为了研究口服重水对肝脏的生物学效应，让大鼠饮用重水与普通水混合的水（30:70）6周。给予重水导致体重逐渐下降，而在整个实验期间肝脏重量略有增加。对磷酸酶和脱氢酶进行了生化分析。酸性磷酸酶、葡萄糖-6-磷酸酶和三磷酸腺苷酶活性下降，而碱性磷酸酶、琥珀酸脱氢酶和乳酸脱氢酶活性均有明显增加。通过生化方法测定，脂质、核酸和蛋白质在整个实验期间因重水喂养而逐渐减少。