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抗菌药物对细菌致病机制的干扰：亚抑菌浓度阿奇霉素对淋球菌菌毛形成及与人上皮细胞黏附的影响

Antimicrobial interference with bacterial mechanisms of pathogenicity: effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells.

作者信息

Gorby G L, McGee Z A

机构信息

Section of Infectious Diseases, Omaha VA Medical Center, Nebraska.

出版信息

Antimicrob Agents Chemother. 1990 Dec;34(12):2445-8. doi: 10.1128/AAC.34.12.2445.

DOI:10.1128/AAC.34.12.2445
PMID:1982402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172082/
Abstract

The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

摘要

研究了亚抑菌浓度的阿奇霉素（CP-62,993）对淋病奈瑟菌菌毛形成和黏附特性的影响。亚抑菌浓度的阿奇霉素通过降低菌毛蛋白亚基的合成，显著降低了表面表达组装菌毛的淋球菌百分比，并大幅降低了淋球菌对人黏膜细胞的黏附。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/5bdc72b21f1f/aac00068-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/d41f9266e07c/aac00068-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/227ad557d340/aac00068-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/5bdc72b21f1f/aac00068-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/d41f9266e07c/aac00068-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/227ad557d340/aac00068-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b61a/172082/5bdc72b21f1f/aac00068-0181-b.jpg

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Loss of pili and decreased attachment to human cells by Neisseria meningitidis and Neisseria gonorrhoeae exposed to subinhibitory concentrations of antibiotics.暴露于亚抑菌浓度抗生素的脑膜炎奈瑟菌和淋病奈瑟菌菌毛丧失，对人细胞的黏附能力降低。
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