Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Inc., Carlton South, Victoria, Australia.
Contact Dermatitis. 2009 Oct;61(4):231-5. doi: 10.1111/j.1600-0536.2009.01610.x.
Patch testing with commercially available kits detects only 70-80% of relevant allergens in patients with contact dermatitis. This is not ideal, especially when occupational issues are being evaluated. This study analyses our data regarding reactions to patients' own products.
In a 5-year period, 1532 patients were assessed in our occupational dermatology clinic.
We found that 101 patients (6.6%) reacted to their own samples. In 20 (1.3%) cases, reacting to their own samples was the only clue for detecting the responsible allergen. In 59 (3.9%) cases, testing with their own samples reinforced their reactions to commercial allergens.
We found the overall additive value of testing with patients' own products to be 5.2%. This is not a low proportion considering the 20-30% false negative rate when patch testing. Patch testing with patients' own samples, appropriately diluted should be undertaken whenever possible.
商业试剂盒进行斑贴试验仅能检测出接触性皮炎患者 70-80%的相关变应原，这并不理想，尤其是在评估职业性问题时。本研究分析了我们对患者自身产品反应的数据。
在 5 年期间，我们的职业皮肤科诊所评估了 1532 名患者。
我们发现 101 名患者（6.6%）对自身样本有反应。在 20 例（1.3%）情况下，对自身样本的反应是发现致敏变应原的唯一线索。在 59 例（3.9%）情况下，自身样本的检测结果加强了对商业变应原的反应。
我们发现患者自身产品检测的总附加价值为 5.2%。考虑到斑贴试验有 20-30%的假阴性率，这一比例并不低。只要有可能，应适当稀释患者自身样本进行斑贴试验。
