在职业皮肤科诊所进行患者自身产品斑贴试验的附加价值。
The additive value of patch testing with patients' own products at an occupational dermatology clinic.
机构信息
Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Inc., Carlton South, Victoria, Australia.
出版信息
Contact Dermatitis. 2009 Oct;61(4):231-5. doi: 10.1111/j.1600-0536.2009.01610.x.
BACKGROUND AND OBJECTIVES
Patch testing with commercially available kits detects only 70-80% of relevant allergens in patients with contact dermatitis. This is not ideal, especially when occupational issues are being evaluated. This study analyses our data regarding reactions to patients' own products.
METHODS
In a 5-year period, 1532 patients were assessed in our occupational dermatology clinic.
RESULTS
We found that 101 patients (6.6%) reacted to their own samples. In 20 (1.3%) cases, reacting to their own samples was the only clue for detecting the responsible allergen. In 59 (3.9%) cases, testing with their own samples reinforced their reactions to commercial allergens.
CONCLUSIONS
We found the overall additive value of testing with patients' own products to be 5.2%. This is not a low proportion considering the 20-30% false negative rate when patch testing. Patch testing with patients' own samples, appropriately diluted should be undertaken whenever possible.
背景与目的
商业试剂盒进行斑贴试验仅能检测出接触性皮炎患者 70-80%的相关变应原，这并不理想，尤其是在评估职业性问题时。本研究分析了我们对患者自身产品反应的数据。
方法
在 5 年期间，我们的职业皮肤科诊所评估了 1532 名患者。
结果
我们发现 101 名患者（6.6%）对自身样本有反应。在 20 例（1.3%）情况下，对自身样本的反应是发现致敏变应原的唯一线索。在 59 例（3.9%）情况下，自身样本的检测结果加强了对商业变应原的反应。
结论
我们发现患者自身产品检测的总附加价值为 5.2%。考虑到斑贴试验有 20-30%的假阴性率，这一比例并不低。只要有可能，应适当稀释患者自身样本进行斑贴试验。
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