Antrum R, Gorst K, Galvin K, Thornton C, Wynne K, Malata C, Ramsden C, Kester R, Harding I
Department of Vascular Surgery, St. James's University Hospital, Leeds, U.K.
Scand J Infect Dis Suppl. 1990;72:45-53.
The preliminary results of a trial to examine and compare the safety, tolerability and efficacy of a single dose of teicoplanin with three doses of cephradine combined with metronidazole are presented in a series of 113 patients undergoing elective vascular surgery. There were no obvious differences in the infection rates and sepsis indicators in either group. Neither drug regimen produced any evidence of renal or hepatic damage, though the levels of three hepatocellular enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl-transferase (GGT), were seen to be transiently elevated, peaking 7 days post-operatively. The trial continues.
一项针对113例接受择期血管手术患者的试验给出了初步结果，该试验旨在检验并比较单剂量替考拉宁与三剂量头孢拉定联合甲硝唑的安全性、耐受性及疗效。两组的感染率和败血症指标均无明显差异。两种药物治疗方案均未出现任何肾或肝损伤的迹象，不过三种肝细胞酶，即天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转移酶（GGT）的水平出现了短暂升高，在术后7天达到峰值。试验仍在继续。
