棕色脂肪的工程改造。
The engineering of brown fat.
机构信息
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.
出版信息
J Mol Cell Biol. 2010 Feb;2(1):23-5. doi: 10.1093/jmcb/mjp035. Epub 2009 Oct 12.
PMID:19825852
Abstract
The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
摘要
棕色脂肪组织和白色脂肪组织的发育起源是不同的，棕色脂肪细胞来源于肌肉前体细胞。PR 结构域包含蛋白 16 与 C/EBPβ一起形成一个谱系转换转录复合物，促进棕色脂肪分化并抑制肌肉细胞分化。
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