Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.
J Mol Cell Biol. 2010 Feb;2(1):23-5. doi: 10.1093/jmcb/mjp035. Epub 2009 Oct 12.
The developmental origins of brown adipose tissue and white adipose tissue are distinct, with brown adipocytes being derived from muscle precursors. PR domain containing 16, together with C/EBPbeta, forms a lineage-switching transcriptional complex which promotes brown fat differentiation and suppresses muscle cell differentiation.
棕色脂肪组织和白色脂肪组织的发育起源是不同的，棕色脂肪细胞来源于肌肉前体细胞。PR 结构域包含蛋白 16 与 C/EBPβ一起形成一个谱系转换转录复合物，促进棕色脂肪分化并抑制肌肉细胞分化。
