经阴道液中板层小体计数预测早产胎膜早破的肺成熟度：一项队列研究。

Predicting lung maturity in preterm rupture of membranes via lamellar bodies count from a vaginal pool: a cohort study.

机构信息

Department of Obstetrics and Gynecology, HaEmek Medical Center, Afula, Israel.

出版信息

Reprod Biol Endocrinol. 2009 Oct 14;7:112. doi: 10.1186/1477-7827-7-112.

DOI:10.1186/1477-7827-7-112

PMID:19828025

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2768717/

Abstract

BACKGROUND

Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity. The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes.

METHODS

In a prospective study, amniotic fluid specimens were collected from a vaginal pool from women after preterm premature rupture of membranes with gestational age between 27 and 36 completed weeks. Receiver operating characteristics curve was estimated to assess the threshold of lamellar bodies' count that may predict fetal lung maturity.

RESULTS

Seventy-five specimens were collected of which 17 were between 32 to 34 weeks. A lamellar bodies' count of 28,000 or more predicted mature fetus 100% of the time (specificity) among all women and also among women between 32 to 34 weeks. The sensitivity was 72% among all and 92% when gestational age was between 32 to 34 weeks. A count of 8,000 or less, predicted respiratory distress syndrome with a sensitivity of 98% among the whole group.

CONCLUSION

Counting of lamellar bodies in amniotic fluid from a vaginal pool may be used to predict fetal lung maturity.

摘要

背景

羊膜穿刺术是获取羊水以进行胎儿肺成熟度检测的公认方法。本研究旨在通过对早产胎膜早破孕妇阴道液中的板层小体进行计数，验证一种非侵入性的胎儿肺成熟度检测方法。

方法

在一项前瞻性研究中，对妊娠 27 至 36 周之间早产胎膜早破的孕妇阴道液中的羊水标本进行了采集。通过受试者工作特征曲线来评估预测胎儿肺成熟度的板层小体计数阈值。

结果

共采集了 75 份标本，其中 17 份在 32 至 34 周之间。在所有孕妇中，板层小体计数达到 28,000 个或更多时，可 100%（特异性）预测胎儿肺成熟（特异性）；在 32 至 34 周的孕妇中，这一比例为 92%。在所有孕妇中，敏感性为 72%；在 32 至 34 周的孕妇中，敏感性为 92%。计数达到 8,000 个或更少时，可预测呼吸窘迫综合征，其在整个组中的敏感性为 98%。