Institute of Biomedical Technology, National Research Council, Milan, Italy.
BMC Bioinformatics. 2009 Oct 15;10 Suppl 12(Suppl 12):I1. doi: 10.1186/1471-2105-10-S12-I1.
In this paper we provide an introduction to the techniques for multi-scale complex biological systems, from the single bio-molecule to the cell, combining theoretical modeling, experiments, informatics tools and technologies suitable for biological and biomedical research, which are becoming increasingly multidisciplinary, multidimensional and information-driven. The most important concepts on mathematical modeling methodologies and statistical inference, bioinformatics and standards tools to investigate complex biomedical systems are discussed and the prominent literature useful to both the practitioner and the theoretician are presented.
本文从单个生物分子到细胞，为多尺度复杂生物系统的技术提供了介绍，结合了适用于生物和生物医学研究的理论建模、实验、信息学工具和技术，这些研究正变得越来越多学科、多维和信息驱动。讨论了用于研究复杂生物医学系统的数学建模方法和统计推断、生物信息学和标准工具的最重要概念，并呈现了对实践者和理论家都有用的突出文献。
