Page D E
Division of Nephrology, Ottawa General Hospital.
Adv Perit Dial. 1990;6:205-6.
Hyponatremia is not uncommon in patients on CAPD, despite the presence of an intraabdominal solution that should preserve normal serum sodium concentration. We have examined the relationship between the plasma renin level and serum sodium concentration in our CAPD patients. Patients with abnormal causes for increased thirst were removed from the study; that is, diabetic patients with fluctuating blood sugar or patients on tricyclic antidepressants or clonidine. In forty-one patients a statistically significant inverse correlation between serum sodium and plasma renin levels was demonstrated. We conclude that thirst stimulation by the renin-angiotensin system contributes to the hyponatremia seen in many patients on CAPD.
尽管持续性非卧床腹膜透析（CAPD）患者腹腔内有可维持正常血清钠浓度的溶液，但低钠血症在这类患者中并不少见。我们研究了CAPD患者血浆肾素水平与血清钠浓度之间的关系。将因异常原因导致口渴增加的患者排除在研究之外，即血糖波动的糖尿病患者或服用三环类抗抑郁药或可乐定的患者。在41例患者中，血清钠与血浆肾素水平之间存在统计学上显著的负相关。我们得出结论，肾素-血管紧张素系统对口渴的刺激导致了许多CAPD患者出现低钠血症。
