Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy.
Int J Infect Dis. 2010 Jun;14(6):e460-8. doi: 10.1016/j.ijid.2009.06.028. Epub 2009 Oct 13.
Fungi are a major threat in immunocompromised patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop fungal diseases. The traditional view of immune suppression as a key risk factor for susceptibility to fungal infections needs to be accommodated within new conceptual advances on host immunity and its relationship to fungal disease. The critical role of the immune system emphasizes the contribution of host genetic polymorphisms to fungal disease susceptibility. This review highlights the present knowledge on innate immunity genetics that associates with susceptibility to fungal diseases.
真菌是免疫功能低下患者的主要威胁。尽管免疫抑制程度相似，但并非所有处于危险中的个体最终都会患上真菌病。需要将免疫抑制作为真菌感染易感性的关键风险因素的传统观点纳入宿主免疫及其与真菌病关系的新概念进展中。免疫系统的关键作用强调了宿主遗传多态性对真菌病易感性的贡献。本文综述了与真菌病易感性相关的固有免疫遗传学的现有知识。
