Speth Cornelia, Rambach Günter, Lass-Flörl Cornelia, Dierich Manfred P, Würzner Reinhard
Institute of Hygiene and Social Medicine, University of Innsbruck, Innsbruck, Austria.
Mycoses. 2004 Apr;47(3-4):93-103. doi: 10.1111/j.1439-0507.2004.00979.x.
New therapeutic approaches enable organ transplantations and guarantee longer survival for AIDS patients or patients with haematological neoplasia. The price for these medical advances is immunosuppression and thus enhanced susceptibility to opportunistic fungal infections. As a consequence invasive fungal infections are on the march in modern medicine. Therapeutic limitations and difficulties strongly demand for a deeper understanding of the interaction between the various fungi and the hosts' innate and adaptive immune defence system. This understanding is the essential prerequisite for a potential therapeutic approach, which may support specifically the insufficient antifungal attack of the host. In the present article, we therefore review the current knowledge of the role of the complement system as a central part of innate immunity and as a fine tuner of adaptive immunity in the pathogenesis of invasive fungal infections, such as aspergillosis, candidosis, cryptococcosis, paracoccidioidomycosis, blastomycosis and histoplasmosis.
新的治疗方法使得器官移植成为可能，并确保艾滋病患者或血液系统肿瘤患者能活得更长。这些医学进步的代价是免疫抑制，从而增加了对机会性真菌感染的易感性。因此，侵袭性真菌感染在现代医学中呈上升趋势。治疗上的局限性和困难强烈要求更深入地了解各种真菌与宿主固有和适应性免疫防御系统之间的相互作用。这种了解是潜在治疗方法的基本前提，该方法可能会特别支持宿主对抗真菌攻击不足的情况。因此，在本文中，我们综述了补体系统作为固有免疫的核心部分以及侵袭性真菌感染（如曲霉病、念珠菌病、隐球菌病、副球孢子菌病、芽生菌病和组织胞浆菌病）发病机制中适应性免疫的微调器所起作用的当前知识。
