Division of Cardiology, Italy.
J Cardiovasc Med (Hagerstown). 2010 Sep;11(9):704-6. doi: 10.2459/JCM.0b013e328332e745.
Bronchopulmonary dysplasia is a common adverse outcome of very premature babies treated with long-lasting ventilation and oxygen therapy. Infants with bronchopulmonary dysplasia may develop pulmonary arterial hypertension. We report on severe bronchopulmonary dysplasia in a preterm infant who developed secondary, symptomatic and progressively severe pulmonary arterial hypertension. He was treated with sildenafil for 12 months, with complete resolution of pulmonary arterial hypertension. Eighteen months after therapy discontinuation, the patient was asymptomatic, and his systolic pulmonary artery pressure was normal. Routine use of sildenafil in preterm infants with bronchopulmonary dysplasia and secondary pulmonary arterial hypertension could be the future; large studies should confirm this report.
支气管肺发育不良是接受长期通气和氧疗的极早产儿常见的不良后果。患有支气管肺发育不良的婴儿可能会发展为肺动脉高压。我们报告了一例早产儿严重支气管肺发育不良，继发症状性和进行性严重肺动脉高压。他接受了西地那非治疗 12 个月，肺动脉高压完全缓解。停药 18 个月后，患者无症状，收缩压肺动脉压正常。常规使用西地那非治疗支气管肺发育不良和继发性肺动脉高压的早产儿可能是未来的方向；大型研究应证实这一报告。
