Department of Pediatrics, Children's Mercy Hospital and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
J Perinatol. 2012 Jan;32(1):64-9. doi: 10.1038/jp.2011.131. Epub 2011 Sep 22.
The objective of this study is to determine the effects that sildenafil citrate has on gas exchange in infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH).
A retrospective review was performed from 2005 to 2009. Infants treated with sildenafil citrate for greater than 48 h were included. Standard patient data was collected, including echocardiogram, inspired oxygen and systemic blood pressure, before and during administration of sildenafil citrate.
Sildenafil citrate was used in 21 preterm infants with BPD-associated PH. A significant reduction in estimated right ventricular peak systolic pressure was seen after initiation of sildenafil citrate, with the majority of infants showing no improvement in gas exchange at 48 h of treatment. Four infants died during treatment.
Sildenafil citrate reduced estimated pulmonary artery pressures, but this reduction was not reflected in improved gas exchange within the first 48 h.
本研究旨在确定枸橼酸西地那非对患有支气管肺发育不良（BPD）相关肺动脉高压（PH）的婴儿的气体交换的影响。
回顾性研究于 2005 年至 2009 年进行。纳入接受枸橼酸西地那非治疗超过 48 小时的婴儿。收集了标准的患者数据，包括超声心动图、吸入氧和全身血压，在开始枸橼酸西地那非治疗前后。
枸橼酸西地那非用于 21 例患有 BPD 相关 PH 的早产儿。在开始枸橼酸西地那非治疗后，估计右心室收缩峰值压力显著降低，但大多数婴儿在治疗 48 小时内的气体交换并未改善。4 名婴儿在治疗期间死亡。
枸橼酸西地那非降低了估计的肺动脉压，但在最初 48 小时内，这种降低并没有反映在改善的气体交换上。
