Kane Abdoul, Hutchison William D, Hodaie Mojgan, Lozano Andres M, Dostrovsky Jonathan O
Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Neuroreport. 2009 Nov 25;20(17):1549-53. doi: 10.1097/WNR.0b013e32833282c8.
In recent years there has been great interest in oscillatory activity in the brain and in the role of pathological oscillations in the basal ganglia in mediating some of the symptoms of Parkinson's disease (PD). In this study, thalamic and subthalamic nucleus local field potentials were intraoperatively recorded from pairs of closely separated microelectrodes in six PD patients ON and OFF dopaminergic medication. Using correlation and coherence analyses, we found high-frequency oscillatory activity in the 110-170 Hz band in thalamus in patients OFF dopamine. These oscillations were significantly reduced after administration of dopamine-replacement therapy. In contrast, activity in the lower frequencies (the theta and beta ranges) was increased. However, in subthalamic nucleus, we observed an increase in high-frequency oscillatory activity (150-200 Hz), and a reduction of the activity in the low-frequency range after levodopa administration. These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy.
近年来，人们对大脑中的振荡活动以及基底神经节中的病理性振荡在介导帕金森病（PD）某些症状中的作用产生了极大兴趣。在本研究中，对6例处于多巴胺能药物“开”和“关”状态的PD患者，术中通过一对紧密间隔的微电极记录丘脑和底丘脑核的局部场电位。使用相关性和相干性分析，我们发现多巴胺“关”状态的患者丘脑中存在110 - 170Hz频段的高频振荡活动。给予多巴胺替代治疗后，这些振荡显著减少。相反，低频（θ和β频段）的活动增加。然而，在底丘脑核中，我们观察到左旋多巴给药后高频振荡活动（150 - 200Hz）增加，低频范围内的活动减少。这些发现证实并扩展了早期的研究结果，表明在PD中基底神经节振荡活动存在显著变化，并且这些变化在多巴胺能治疗后可以逆转。
